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Article

Cancer-Related Mutations Are Not Enriched in Naive Human Pluripotent Stem Cells.

Cell stem cell - 7 Jan 2021

Stirparo Giuliano Giuseppe, Smith Austin, Guo Ge

Abstract excerpt

Previous analysis of RNA sequencing (RNA-seq) data from human naive pluripotent stem cells reported multiple point "mutations" in cancer-related genes and implicated selective culture conditions. We observed, however, that those mutations were only present in co-cultures with mouse feeder cells. Inspection of reads containing the polymorphisms revealed complete identity to the mouse reference genome. After we...

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Identifiers

PMID: 33321074
DOI: 10.1016/j.stem.2020.11.014
PMCID: PMC7837212

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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