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Article

Low incidence of DNA sequence variation in human induced pluripotent stem cells generated by nonintegrating plasmid expression.

Cell stem cell - 2 Mar 2012

Cheng Linzhao, Hansen Nancy F, Zhao Ling, Du Yutao, Zou Chunlin, Donovan Frank X, Chou Bin-Kuan, Zhou Guangyu, Li Shijie, Dowey Sarah N, Ye Zhaohui, Chandrasekharappa Settara C, Yang Huanming, Mullikin James C, Liu P Paul

Abstract excerpt

The utility of induced pluripotent stem cells (iPSCs) as models to study diseases and as sources for cell therapy depends on the integrity of their genomes. Despite recent publications of DNA sequence variations in the iPSCs, the true scope of such changes for the entire genome is not clear. Here we report the whole-genome sequencing of three human iPSC lines derived from two cell types of an adult donor by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22385660
DOI: 10.1016/j.stem.2012.01.005
PMCID: PMC3298448

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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