Article
HIV-1 evades a Gag mutation that abrogates killer cell immunoglobulin-like receptor binding and disinhibits natural killer cells in infected individuals with KIR2DL2+/HLA-C*03: 04+ genotype.
AIDS (London, England) - 1 Jan 2021
Ziegler Maja C, Naidoo Kewreshini, Chapel Anais, Nkotwana Sindiswa, Mann Jaclyn, Mncube Zenele, Ismael Nasreen, Goulder Philip, Ndung'u Thumbi, Altfeld Marcus, Thobakgale Christina F
Abstract excerpt
: HIV-1 sequence variations impact binding of inhibitory killer cell immunoglobulin-like receptors (KIRs) to human leukocyte antigen class I (HLA-I) molecules modulating natural killer cell function. HIV-1 strains encoding amino acids that mediate binding of inhibitory KIRs might therefore have a selective benefit in individuals expressing the respective KIR/HLA genotypes. Here, we demonstrate that HIV-1 clade C...
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