Article
Activating Killer Immunoglobulin Receptors and HLA-C: a successful combination providing HIV-1 control.
Scientific reports - 13 Feb 2017
Malnati Mauro S, Ugolotti Elisabetta, Monti Maria Cristina, Battista Davide De, Vanni Irene, Bordo Domenico, Sironi Francesca, Larghero Patrizia, Marco Eddi Di, Biswas Priscilla, Poli Guido, Vicenzi Elisa, Riva Agostino, Tarkowski Maciej, Tambussi Giuseppe, Nozza Silvia, Tripodi Gino, Marras Francesco, De Maria Andrea, Pistorio Angela, Biassoni Roberto
Abstract excerpt
Several studies demonstrated a relevant role of polymorphisms located within the HLA-B and -C loci and the Killer Immunoglobulin Receptors (KIRs) 3DL1 and 3DS1 in controlling HIV-1 replication. KIRs are regulatory receptors expressed at the surface of NK and CD8+ T-cells that specifically bind HLA-A and -B alleles belonging to the Bw4 supratype and all the -C alleles expressing the C1 or C2 supratype. We here...
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