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Article

HIV-1 Control by NK Cells via Reduced Interaction between KIR2DL2 and HLA-C∗12:02/C∗14:03.

Cell reports - 22 Nov 2016

Lin Zhansong, Kuroki Kimiko, Kuse Nozomi, Sun Xiaoming, Akahoshi Tomohiro, Qi Ying, Chikata Takayuki, Naruto Takuya, Koyanagi Madoka, Murakoshi Hayato, Gatanaga Hiroyuki, Oka Shinichi, Carrington Mary, Maenaka Katsumi, Takiguchi Masafumi

Abstract excerpt

Natural killer (NK) cells control viral infection in part through the interaction between killer cell immunoglobulin-like receptors (KIRs) and their human leukocyte antigen (HLA) ligands. We investigated 504 anti-retroviral (ART)-free Japanese patients chronically infected with HIV-1 and identified two KIR/HLA combinations, KIR2DL2/HLA-C∗12:02 and KIR2DL2/HLA-C∗14:03, that impact suppression of HIV-1 replication....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27880898
DOI: 10.1016/j.celrep.2016.10.075
PMCID: PMC5184766

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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