Selection of an HLA-C*03:04-Restricted HIV-1 p24 Gag Sequence Variant Is Associated with Viral Escape from KIR2DL3+ Natural Killer Cells: Data from an Observational Cohort in South Africa.

doi:10.1371/journal.pmed.1001900

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Article

Selection of an HLA-C*03:04-Restricted HIV-1 p24 Gag Sequence Variant Is Associated with Viral Escape from KIR2DL3+ Natural Killer Cells: Data from an Observational Cohort in South Africa.

PLoS medicine - 1 Nov 2015

Hölzemer Angelique, Thobakgale Christina F, Jimenez Cruz Camilo A, Garcia-Beltran Wilfredo F, Carlson Jonathan M, van Teijlingen Nienke H, Mann Jaclyn K, Jaggernath Manjeetha, Kang Seung-gu, Körner Christian, Chung Amy W, Schafer Jamie L, Evans David T, Alter Galit, Walker Bruce D, Goulder Philip J, Carrington Mary, Hartmann Pia, Pertel Thomas, Zhou Ruhong, Ndung'u Thumbi, Altfeld Marcus

Abstract excerpt

BACKGROUND: Viruses can evade immune surveillance, but the underlying mechanisms are insufficiently understood. Here, we sought to understand the mechanisms by which natural killer (NK) cells recognize HIV-1-infected cells and how this virus can evade NK-cell-mediated immune pressure. METHODS AND FINDINGS: Two sequence mutations in p24 Gag associated with the presence of specific KIR/HLA combined genotypes were...

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Share to gag Gene Products, Human Immunodeficiency Virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HIV Core Protein p24

Share to HLA-C Antigens

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Identifiers

PMID: 26575988
DOI: 10.1371/journal.pmed.1001900
PMCID: PMC4648589

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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