Article
KIR-HLA genotypes in HIV-infected patients lacking immunological recovery despite effective antiretroviral therapy.
PloS one - 1 Jan 2011
Soria Alessandro, Guerini Franca Rosa, Bandera Alessandra, Bolognesi Elisabetta, Uglietti Alessia, Fusco Caterina, Zucchi Patrizia, Maserati Renato, Rizzardini Giuliano, Clerici Mario, Gori Andrea
Abstract excerpt
BACKGROUND: In HIV-infected individuals, mechanisms underlying unsatisfactory immune recovery during effective combination antiretroviral therapy (cART) have yet to be fully understood. We investigated whether polymorphism of genes encoding immune-regulating molecules, such as killer immunoglobulin-like receptors (KIR) and their ligands class I human leukocyte antigen (HLA), could influence immunological response...
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