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Article

Investigating the causal effect of fibroblast growth factor 23 on osteoporosis and cardiometabolic disorders: A Mendelian randomization study.

Bone - 1 Feb 2021

Yokomoto-Umakoshi Maki, Umakoshi Hironobu, Miyazawa Takashi, Ogata Masatoshi, Sakamoto Ryuichi, Ogawa Yoshihiro

Abstract excerpt

Pathological excess of fibroblast growth factor 23 (FGF23) causes mineral and bone disorders. However, the causality of FGF23 in the development of osteoporosis remains unknown. Whether FGF23 has systemic effects on cardiometabolic disorders beyond regulating mineral metabolism is also controversial. In this study, we investigated the causal effect of FGF23 on osteoporosis and cardiometabolic disorders using...

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Identifiers

PMID: 33253933
DOI: 10.1016/j.bone.2020.115777

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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