Article
Causal associations between insulin-like growth factor binding protein-1 to -7 and osteoporosis: A two-sample Mendelian randomization study.
Medicine - 21 Nov 2025
Du Peng, Li Tusheng, Fan Ning, Wang Baodong, Wang Tianyi, Zang Lei
Abstract excerpt
Insulin-like growth factor binding proteins (IGFBPs) are important regulatory factors of bone metabolism. However, the association between IGFBPs and osteoporosis remains a subject of contention in observational studies. We conducted a 2-sample Mendelian randomization (MR) study to assess the causal relationship between IGFBP 1-7 and osteoporosis using publicly available genome-wide association study summary...
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