Unveiling the Etiology of Osteoporosis Onset: A Mendelian Randomization Investigation

Abstract excerpt

<title>Abstract</title> <p>Objective Osteoporosis (OP) is a prevalent systemic metabolic disorder characterized by a reduction in total bone mass and a deterioration of bone microarchitecture. These changes result in significantly increased bone fragility, which predisposes patients to a higher risk of fractures. As a consequence, OP severely impacts patients' quality of life and imposes a considerable economic...

Topics

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• Bone Density
• Bone Diseases, Metabolic
• Genome-Wide Association Study
• Mendelian Randomization Analysis
• Osteoarthritis, Hip
• Osteoarthritis, Knee
• Osteoporosis
• Polymorphism, Single Nucleotide

Identifiers and source

Literature Corpus work

6c1b9fc7-40aa-5e4a-b1ae-547c27fea870

DOI

10.21203/rs.3.rs-4979145/v1