Are blood lipids risk factors for fracture? Integrative evidence from instrumental variable causal inference and mediation analysis using genetic data.

Abstract excerpt

BACKGROUND: The relationship between lipids and the risk of fracture is currently controversial and whether such association is causal remains elusive. METHODS: We performed two-sample inverse variance weighted (IVW) Mendelian randomization (MR) analyses to evaluate causal effects of four lipids (i.e. high-density lipoprotein cholesterol [HDL], low-density lipoprotein cholesterol [LDL], total cholesterol [TC] and...

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