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Article

Unveiling the Causal Relationship Between Osteoporosis and Circulating Metabolites from a Genetic Perspective.

Journal of musculoskeletal & neuronal interactions - 1 Dec 2025

Wan Peng, Zheng Yimin

Abstract excerpt

OBJECTIVES: Osteoporosis (OP) is a major public health concern characterized by increased bone fragility. This study aimed to investigate the causal relationship between circulating metabolites, particularly lipid-related metabolites, and OP using Mendelian Randomization (MR). METHODS: A bidirectional two-sample MR approach was applied using summary statistics from large-scale Genome-Wide Association Studies...

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Share to Genetic Predisposition to Disease
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 41324219
PMCID: PMC12684268

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