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Article

Fibroblast Growth Factor-23 and Risk of Cardiovascular Diseases: A Mendelian Randomization Study.

Clinical journal of the American Society of Nephrology : CJASN - 1 Jan 2023

Donovan Killian, Herrington William G, Paré Guillaume, Pigeyre Marie, Haynes Richard, Sardell Rebecca, Butterworth Adam S, Folkersen Lasse, Gustafsson Stefan, Wang Qin, Baigent Colin, Mälarstig Anders, Holmes Michael V, Staplin Natalie

Abstract excerpt

BACKGROUND: Fibroblast growth factor-23 (FGF-23) is associated with a range of cardiovascular and noncardiovascular diseases in conventional epidemiological studies, but substantial residual confounding may exist. Mendelian randomization approaches can help control for such confounding. METHODS: SCALLOP Consortium data of 19,195 participants were used to generate an FGF-23 genetic score. Data from 337,448 UK...

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Identifiers

PMID: 36719157
DOI: 10.2215/CJN.05080422
PMCID: PMC7614195

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