Article
Using Mendelian Randomization to Decipher Mechanisms of Bone Disease
9 Sept 2018
Abstract excerpt
PURPOSE OF REVIEW: This review summarizes the basic principles of Mendelian randomization (MR) and provides evidence for the causal effect of multiple modifiable factors on bone outcomes. RECENT FINDINGS: Several studies using MR approach have provided support for the causal effect of obesity on bone mineral density (BMD). Strikingly, studies have failed to prove a causal association between elevated 25(OH) D...