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Article

Effects of FGF21 overexpression in osteoporosis and bone mineral density: a two-sample, mediating Mendelian analysis.

Frontiers in endocrinology - 1 Jan 2024

Liu Jingjing, Jiang Jun, Li Yunjia, Chen Qiaojun, Yang Ting, Lei Yanfa, He Zewei, Wang Xiaowei, Na Qiang, Lao Changtao, Luo Xinlei, Yang Lirong, Yang Zhengchang

Abstract excerpt

Objective: Fibroblast growth factor 21 (FGF21) is a secreted protein that regulates body metabolism. In recent years, many observational studies have found that FGF21 is closely related to bone mineral density and osteoporosis, but the causal relationship between them is still unclear. Therefore, this study used two-sample, mediated Mendelian randomization (MR) analysis to explore the causal relationship between...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39296716
DOI: 10.3389/fendo.2024.1439255
PMCID: PMC11409249

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