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Article

Research on DnaA in the early days.

Research in microbiology - 1 Dec 2020

Kohiyama Masamichi

Abstract excerpt

The Escherichia coli chromosome is a circular double helix. DNA polymerase, therefore, cannot use it directly as a template for polymerization until it has first been unwound. The DnaA protein opens the chromosome at a unique and specific site (oriC), which allows the polymerase to begin DNA replication. François Jacob and Sydney Brenner predicted the existence of the initiator protein, DnaA, back in the early...

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Identifiers

PMID: 33245995
DOI: 10.1016/j.resmic.2020.11.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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