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Article

Reversal of morphine-induced cell-type-specific synaptic plasticity in the nucleus accumbens shell blocks reinstatement.

Proceedings of the National Academy of Sciences of the United States of America - 19 Jan 2016

Hearing Matthew C, Jedynak Jakub, Ebner Stephanie R, Ingebretson Anna, Asp Anders J, Fischer Rachel A, Schmidt Clare, Larson Erin B, Thomas Mark John

Abstract excerpt

Drug-evoked plasticity at excitatory synapses on medium spiny neurons (MSNs) of the nucleus accumbens (NAc) drives behavioral adaptations in addiction. MSNs expressing dopamine D1 (D1R-MSN) vs. D2 receptors (D2R-MSN) can exert antagonistic effects in drug-related behaviors, and display distinct alterations in glutamate signaling following repeated exposure to psychostimulants; however, little is known of...

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PMID: 26739562
DOI: 10.1073/pnas.1519248113
PMCID: PMC4725472

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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