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Article

Cocaine-induced locomotor activity and cocaine discrimination in dopamine D2 receptor mutant mice.

Psychopharmacology - 1 Aug 2002

Chausmer Allison L, Elmer Gregory I, Rubinstein Marcelo, Low Malcolm J, Grandy David K, Katz Jonathan L

Abstract excerpt

RATIONALE: Dopamine (DA) D2-like antagonists block several effects of cocaine, including its locomotor stimulant and interoceptive discriminative-stimulus effects. Because these compounds generally lack selectivity among the D2-like DA receptors, the specific roles of the subtypes remain unclear. OBJECTIVES: DA D2 receptor knockout (DA D2R KO), heterozygous (HET), and wild-type (WT) mice were used to study the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Dose-Response Relationship, Drug

Share to Mice, Knockout

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Share to Receptors, Dopamine D2

Source

Identifiers

PMID: 12185400
DOI: 10.1007/s00213-002-1142-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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