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Article

Diminished role of dopamine D1-receptor signaling with the development of an addicted phenotype in rats.

Biological psychiatry - 1 Jul 2014

Ramôa Carolina P, Doyle Susan E, Lycas Matthew D, Chernau Andrea K, Lynch Wendy J

Abstract excerpt

BACKGROUND: Although considerable evidence implicates dopamine D1-receptor signaling in the nucleus accumbens in motivation for cocaine during early stages of addiction, less is known with regard to its role after the development of addiction. Here, we examined its role in the development of an addicted phenotype in intact male and female rats, and in female rats that were either resistant or vulnerable to...

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Source

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Identifiers

PMID: 24199666
DOI: 10.1016/j.biopsych.2013.09.028
PMCID: PMC3976474

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