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Sex differences and addiction severity influence methadone, buprenorphine, and naltrexone efficacy on oxycodone motivation in genetically diverse rat

2025-05-13

Abstract excerpt

<h4>Background: </h4> and Purpose: Opioid use disorder (OUD) is a major public health issue. Medications like buprenorphine, methadone, and naltrexone show variable efficacy in reducing opioid craving and use in humans. However, it is unclear if similar individual differences exist in animal models. This study investigated how sex and addiction severity impact these medications’ efficacy in genetically diverse rat...

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Literature Corpus work
f7100d84-c509-5ffa-9590-37567c6c64e3
DOI
10.22541/au.174713608.89988727/v1
Open publication

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Sex differences and addiction severity influence methadone, buprenorphine, and naltrexone efficacy on oxycodone motivation in genetically diverse ratDOI 10.22541/au.174713608.89988727/v1
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