Article
A shift in the role of glutamatergic signaling in the nucleus accumbens core with the development of an addicted phenotype.
Biological psychiatry - 15 Nov 2014
Doyle Susan E, Ramôa Carolina, Garber Garrett, Newman Joshua, Toor Zeeshan, Lynch Wendy J
Abstract excerpt
BACKGROUND: While dopamine signaling in the nucleus accumbens (NAc) plays a well-established role in motivating cocaine use in early nonaddicted stages, recent evidence suggests that other signaling pathways may be critical once addiction has developed. Given the importance of glutamatergic signaling in the NAc for drug seeking and relapse, here we examined its role in motivating cocaine self-administration under...
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