Article
Cocaine-induced locomotor activity and cocaine discrimination in dopamine D4 receptor mutant mice.
Psychopharmacology - 1 Oct 2003
Katz Jonathan L, Chausmer Allison L, Elmer Gregory I, Rubinstein Marcelo, Low Malcolm J, Grandy David K
Abstract excerpt
RATIONALE: Previous studies have found a role for dopamine D(2)-like receptors in many of the behavioral effects of cocaine, including its stimulation of locomotor activity and interoceptive discriminative-stimulus effects. However, given the lack of selectivity of most of the available pharmacological tools among D(2), D(3) and D(4) dopamine receptors, the roles of these specific receptors remain unclear....
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