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Article

Clonal haematopoiesis in chronic ischaemic heart failure: prognostic role of clone size for DNMT3A- and TET2-driver gene mutations.

European heart journal - 20 Jan 2021

Assmus Birgit, Cremer Sebastian, Kirschbaum Klara, Culmann David, Kiefer Katharina, Dorsheimer Lena, Rasper Tina, Abou-El-Ardat Khalil, Herrmann Eva, Berkowitsch Alexander, Hoffmann Jedrzej, Seeger Florian, Mas-Peiro Silvia, Rieger Michael A, Dimmeler Stefanie, Zeiher Andreas M

Abstract excerpt

AIMS: Somatic mutations of the epigenetic regulators DNMT3A and TET2 causing clonal expansion of haematopoietic cells (clonal haematopoiesis; CH) were shown to be associated with poor prognosis in chronic ischaemic heart failure (CHF). The aim of our analysis was to define a threshold of variant allele frequency (VAF) for the prognostic significance of CH in CHF. METHODS AND RESULTS: We analysed bone marrow and...

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PMID: 33241418
DOI: 10.1093/eurheartj/ehaa845

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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