Article
Prevalence, predictors, and outcomes of clonal hematopoiesis in individuals aged ≥80 years.
Blood advances - 27 Apr 2021
van Zeventer Isabelle A, Salzbrunn Jonas B, de Graaf Aniek O, van der Reijden Bert A, Boezen H Marike, Vonk Judith M, van der Harst Pim, Schuringa Jan Jacob, Jansen Joop H, Huls Gerwin
Abstract excerpt
Clonal hematopoiesis (CH), characterized by a fraction of peripheral blood cells carrying an acquired genetic variant, emerges with age. Although in general CH is associated with increased mortality and morbidity, no higher risk of death was observed for individuals ≥80 years. Here, we investigated CH in 621 individuals aged ≥80 years from the population-based LifeLines cohort. Sensitive error-corrected...
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