Article
Clonal Hematopoiesis Has Prognostic Value in Dilated Cardiomyopathy Independent of Age and Clone Size.
JACC. Heart failure - 1 May 2024
Sikking Maurits A, Stroeks Sophie L V M, Henkens Michiel T H M, Raafs Anne G, Cossins Benjamin, van Deuren Rosanne C, Steehouwer Marlies, Riksen Niels P, van den Wijngaard Arthur, Brunner Han G, Hoischen Alexander, Verdonschot Job A J, Heymans Stephane R B
Abstract excerpt
BACKGROUND: Clonal hematopoiesis (CH) gives rise to mutated leukocyte clones that induce cardiovascular inflammation and thereby impact the disease course in atherosclerosis and ischemic heart failure. CH of indeterminate potential refers to a variant allele frequency (VAF) (a marker for clone size) in blood of ≥2%. The impact of CH clones-including small clone sizes (VAF <0.5%)-in nonischemic dilated...
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