Article
Prevalence and prognostic significance of DNMT3A- and TET2- clonal haematopoiesis-driver mutations in patients presenting with ST-segment elevation myocardial infarction.
EBioMedicine - 1 Apr 2022
Wang Shengfang, Hu Sining, Luo Xing, Bao Xiaoyi, Li Ji, Liu Minghao, Lv Ying, Zhao Chen, Zeng Ming, Chen Xi, Unsworth Amanda, Jones Sarah, Johnson Thomas W, White Stephen J, Jia Haibo, Yu Bo
Abstract excerpt
BACKGROUND: Clonal haematopoiesis driven by mutations in DNMT3A or TET2 has recently been identified as a new risk factor for cardiovascular disease. Experimental studies suggest that these mutations may enhance inflammation which accelerates the disease progression. We aim to investigate the prevalence of mutations in DNMT3A and TET2 and their association with prognosis of patients with ST-segment elevation...
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