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Article

Clonal Hematopoiesis and Risk of Progression of Heart Failure With Reduced Left Ventricular Ejection Fraction.

Journal of the American College of Cardiology - 13 Apr 2021

Pascual-Figal Domingo A, Bayes-Genis Antoni, Díez-Díez Miriam, Hernández-Vicente Álvaro, Vázquez-Andrés David, de la Barrera Jorge, Vazquez Enrique, Quintas Ana, Zuriaga María A, Asensio-López Mari C, Dopazo Ana, Sánchez-Cabo Fátima, Fuster José J

Abstract excerpt

BACKGROUND: Clonal hematopoiesis driven by somatic mutations in hematopoietic cells, frequently called clonal hematopoiesis of indeterminate potential (CHIP), has been associated with adverse cardiovascular outcomes in population-based studies and in patients with ischemic heart failure (HF) and reduced left ventricular ejection fraction (LVEF). Yet, the impact of CHIP on HF progression, including nonischemic...

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Identifiers

PMID: 33832602
DOI: 10.1016/j.jacc.2021.02.028

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