Article
Full spectrum of clonal haematopoiesis-driver mutations in chronic heart failure and their associations with mortality.
ESC heart failure - 1 Jun 2021
Kiefer Katharina C, Cremer Sebastian, Pardali Evangelia, Assmus Birgit, Abou-El-Ardat Khalil, Kirschbaum Klara, Dorsheimer Lena, Rasper Tina, Berkowitsch Alexander, Serve Hubert, Dimmeler Stefanie, Zeiher Andreas M, Rieger Michael A
Abstract excerpt
AIMS: Somatic mutations in haematopoietic stem cells can lead to the clonal expansion of mutated blood cells, known as clonal haematopoiesis (CH). Mutations in the most prevalent driver genes DNMT3A and TET2 with a variant allele frequency (VAF) ≥ 2% have been associated with atherosclerosis and chronic heart failure of ischemic origin (CHF). However, the effects of mutations in other driver genes for CH with low...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.