Supplemental Association of Clonal Hematopoiesis With Incident Heart Failure.

doi:10.1016/j.jacc.2021.04.085

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Article

Supplemental Association of Clonal Hematopoiesis With Incident Heart Failure.

Journal of the American College of Cardiology - 6 Jul 2021

Yu Bing, Roberts Mary B, Raffield Laura M, Zekavat Seyedeh Maryam, Nguyen Ngoc Quynh H, Biggs Mary L, Brown Michael R, Griffin Gabriel, Desai Pinkal, Correa Adolfo, Morrison Alanna C, Shah Amil M, Niroula Abhishek, Uddin Md Mesbah, Honigberg Michael C, Ebert Benjamin L, Psaty Bruce M, Whitsel Eric A, Manson JoAnn E, Kooperberg Charles, Bick Alexander G, Ballantyne Christie M, Reiner Alex P, Natarajan Pradeep, Eaton Charles B

Abstract excerpt

BACKGROUND: Age-related clonal hematopoiesis of indeterminate potential (CHIP), defined as clonally expanded leukemogenic sequence variations (particularly in DNMT3A, TET2, ASXL1, and JAK2) in asymptomatic individuals, is associated with cardiovascular events, including recurrent heart failure (HF). OBJECTIVES: This study sought to evaluate whether CHIP is associated with incident HF. METHODS: CHIP status was...

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PMID: 34210413
DOI: 10.1016/j.jacc.2021.04.085
PMCID: PMC8313294

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