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Article

Shared genetic architecture and therapeutic targets across paediatric immune-mediated diseases.

Annals of the rheumatic diseases - 1 Sept 2026

Li Jin, Qu Hui-Qi, March Michael E, Glessner Joseph T, Fu Yuqiao, Chen Jiayue, Xu Yang, Chen Hao, Li Yun R, Xia Qianghua, Mentch Frank D, Youssefian Leila, Vahidnezhad Hassan, Saeidian Amir H, Chang Xiao, Liu Wei, Wei Wei, Hakonarson Hakon

Abstract excerpt

OBJECTIVES: Paediatric-onset immune-mediated inflammatory diseases (IMIDs), including juvenile idiopathic arthritis and related rheumatic diseases, remain genetically undercharacterised. We aimed to define shared and category-specific genetic architecture across paediatric IMIDs, compare signals with adult IMIDs, and identify therapeutic opportunities. METHODS: We analysed 24 paediatric IMIDs classified as...

Read the complete abstract on PubMed

Topics

Humans
Genome-Wide Association Study
Child
Polymorphism, Single Nucleotide
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Autoimmune Diseases

Immune System Diseases

Multifactorial Inheritance

Adolescent

Female

Male

Source

Identifiers

PMID: 42575758
DOI: 10.1016/j.ard.2026.07.007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 21 Oct 2026.

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