Article

An integrative multi-omics analysis of 16 autoimmune diseases and cancer outcomes highlights immune-cell regulatory mechanisms and shared genetic architecture

2020-11-30

Abstract excerpt

<h4>Background</h4> Developing functional understanding into the causal molecular drivers of immunological disease is a critical challenge in genomic medicine. Here we systematically apply Mendelian randomization (MR), genetic colocalization, immune cell-type enrichment and phenome-wide association methods to investigate the effect of genetically predicted gene expression on 12 autoimmune and 4 cancer outcomes. <h...

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Literature Corpus work: 3834c138-fa7a-5d6f-909c-574502e26fbb
DOI: 10.1101/2020.11.27.20235663

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