Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mapping the genetic landscape of immune-mediated disorders: potential implications for classification and therapeutic strategies.

Frontiers in immunology - 1 Jan 2025

Fominykh Vera, Shadrin Alexey A, Jaholkowski Piotr, Fuhrer Julian, Parker Nadine, Wiström Erik D, Frei Oleksandr, Smeland Olav B, Sanner Helga, Djurovic Srdjan, Andreassen Ole A

Abstract excerpt

Objectives: Based on clinical, biomarker, and genetic data, McGonagle and McDermott suggested that autoimmune and autoinflammatory disorders can be classified as a disease continuum from purely autoimmune to autoinflammatory with mixed diseases in between. However, the genetic architecture of this spectrum has not been systematically described. Here, we investigate the continuum of polygenic immune-mediated...

Read the complete abstract on PubMed

Topics

Humans
Genome-Wide Association Study
Genetic Predisposition to Disease
Immune System Diseases
Autoimmune Diseases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Linkage Disequilibrium

Multifactorial Inheritance

Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 40406108
DOI: 10.3389/fimmu.2025.1543781
PMCID: PMC12094916

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mapping the genetic landscape of immune-mediated disorders: potential implications for classification and therapeutic strategies.PMID 40406108Read ↗

Mapping the genetic landscape of disorders on the autoimmune-autoinflammatory continuum: potential implications for classification and treatmentSemantic proximity Read ↗

Cross-disorder genetic analysis of immune diseases reveals distinct disease groups and associated genes that converge on common pathogenic pathwaysSemantic proximity Read ↗

Genetic Profiling of Autoimmune Diseases and Exploring Clusters Through Polygenic Risk Score Analysis Using Cohort Data from the UK BiobankSemantic proximity Read ↗

Examining the Genetic Links between Clusters of Immune-mediated Diseases and Psychiatric DisordersSemantic proximity Read ↗

Immune-mediated disease genetics: the shared basis of pathogenesis.Semantic proximity Read ↗

PheWAS and cross-disorder analyses reveal genetic architecture, pleiotropic loci and phenotypic correlations across 11 autoimmune disordersSemantic proximity Read ↗

Human genetics offers an emerging picture of common pathways and mechanisms in autoimmunity.Semantic proximity Read ↗

PheWAS and cross-disorder analysis reveal genetic architecture, pleiotropic loci and phenotypic correlations across 11 autoimmune disorders.Semantic proximity Read ↗

Joint analysis reveals shared autoimmune disease associations and identifies common mechanismsSemantic proximity Read ↗

The immunogenetic architecture of autoimmune disease.Semantic proximity Read ↗

Genetic mapping across autoimmune diseases reveals shared associations and mechanisms.Semantic proximity Read ↗

Genetics of immune-mediated inflammatory diseases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.