Article
A survey of genome-wide association studies, polygenic scores and UK Biobank highlights resources for autoimmune disease genetics.
Frontiers in immunology - 1 Jan 2022
Saurabh Rochi, Fouodo Césaire J K, König Inke R, Busch Hauke, Wohlers Inken
Abstract excerpt
Autoimmune diseases share a general mechanism of auto-antigens harming tissues. Still. they are phenotypically diverse, with genetic as well as environmental factors contributing to their etiology at varying degrees. Associated genomic loci and variants have been identified in numerous genome-wide association studies (GWAS), whose results are increasingly used for polygenic scores (PGS) that are used to predict...
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