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Article

Cross-disorder genetic analysis of immune diseases reveals distinct gene associations that converge on common pathways.

Nature communications - 12 May 2023

Demela Pietro, Pirastu Nicola, Soskic Blagoje

Abstract excerpt

Genome-wide association studies (GWAS) have mapped thousands of susceptibility loci associated with immune-mediated diseases. To assess the extent of the genetic sharing across nine immune-mediated diseases we apply genomic structural equation modelling to GWAS data from European populations. We identify three disease groups: gastrointestinal tract diseases, rheumatic and systemic diseases, and allergic diseases....

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Share to Genetic Predisposition to Disease
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leukocytes, Mononuclear

Share to Polymorphism, Single Nucleotide

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Identifiers

PMID: 37173304
DOI: 10.1038/s41467-023-38389-6
PMCID: PMC10182075

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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