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Article

Embracing diversity: how can broadly neutralizing antibodies effectively target a diverse HIV-1 reservoir?

Current opinion in pharmacology - 1 Oct 2020

Wilson Andrew, Lynch Rebecca M

Abstract excerpt

Genetic diversity in the latent proviral reservoir of HIV-1 infected individuals poses a challenge to cure strategies. It has become increasingly evident that diversity increases proportionally with length of active infection, and that functional and/or sterilizing cure strategies will need to overcome this obstacle in individuals who initiated antiretroviral therapy (ART) during chronic infection. Analyzing the...

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PMID: 33189993
DOI: 10.1016/j.coph.2020.10.004

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