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Predicting the broadly neutralizing antibody susceptibility of the HIV reservoir

4 Sept 2019

Abstract excerpt

Broadly neutralizing antibodies (bNAbs) against HIV-1 are under evaluation for both prevention and therapy. HIV-1 sequence diversity observed in most HIV-infected individuals and archived variations in critical bNAb epitopes present a major challenge for the clinical application of bNAbs, as preexistent resistant viral strains can emerge, resulting in bNAb failure to control HIV. In order to identify viral...

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PMID: 31484826
DOI: 10.1172/jci.insight.130153

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