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Article

HIV-1 neutralizing antibody response and viral genetic diversity characterized with next generation sequencing.

Virology - 1 Jan 2015

Carter Christoph C, Wagner Gabriel A, Hightower George K, Caballero Gemma, Phung Pham, Richman Douglas D, Pond Sergei L Kosakovsky, Smith Davey M

Abstract excerpt

To better understand the dynamics of HIV-specific neutralizing antibody (NAb), we examined associations between viral genetic diversity and the NAb response against a multi-subtype panel of heterologous viruses in a well-characterized, therapy-naïve primary infection cohort. Using next generation sequencing (NGS), we computed sequence-based measures of diversity within HIV-1 env, gag and pol, and compared them to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25463602
DOI: 10.1016/j.virol.2014.10.019
PMCID: PMC4259848

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