Article
Autozygosity influences cardiometabolic disease-associated traits in the AWI-Gen sub-Saharan African study.
Nature communications - 13 Nov 2020
Ceballos Francisco C, Hazelhurst Scott, Clark David W, Agongo Godfred, Asiki Gershim, Boua Palwende R, Xavier Gómez-Olivé F, Mashinya Felistas, Norris Shane, Wilson James F, Ramsay Michèle
Abstract excerpt
The analysis of the effects of autozygosity, measured as the change of the mean value of a trait among offspring of genetic relatives, reveals the existence of directional dominance or overdominance. In this study we detect evidence of the effect of autozygosity in 4 out of 13 cardiometabolic disease-associated traits using data from more than 10,000 sub-Saharan African individuals recruited from Ghana, Burkina...
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