Article
Effect of inbreeding on type 2 diabetes-related metabolites in a Dutch genetic isolate
2019-04-25
Abstract excerpt
Autozygosity, meaning inheritance of an ancestral allele in the homozygous state is known to lead bi-allelic mutations that manifest their effects through the autosomal recessive inheritance pattern. Autosomal recessive mutations are known to be the underlying cause of several Mendelian metabolic diseases, especially among the offspring of related individuals. In line with this, inbreeding coefficient of an indivi...
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Identifiers and source
- Literature Corpus work
- 08ddd46f-9770-50ed-b8c9-0fd7f2bfa635
- DOI
- 10.1101/618801