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Article

Genomic partitioning of inbreeding depression in humans.

American journal of human genetics - 5 Aug 2021

Yengo Loic, Yang Jian, Keller Matthew C, Goddard Michael E, Wray Naomi R, Visscher Peter M

Abstract excerpt

Across species, offspring of related individuals often exhibit significant reduction in fitness-related traits, known as inbreeding depression (ID), yet the genetic and molecular basis for ID remains elusive. Here, we develop a method to quantify enrichment of ID within specific genomic annotations and apply it to human data. We analyzed the phenomes and genomes of ∼350,000 unrelated participants of the UK...

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Identifiers

PMID: 34214457
DOI: 10.1016/j.ajhg.2021.06.005
PMCID: PMC8387293

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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