Associations of genome-wide and regional autozygosity with 96 complex traits in old order Amish.

doi:10.1186/s12864-023-09208-5

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Article

Associations of genome-wide and regional autozygosity with 96 complex traits in old order Amish.

BMC genomics - 20 Mar 2023

Lynch Megan T, Maloney Kristin A, Xu Huichun, Perry James A, Center Regeneron Genetics, Shuldiner Alan R, Mitchell Braxton D

Abstract excerpt

BACKGROUND: Autozygosity, the proportion of the genome that is homozygous by descent, has been associated with variation in multiple health-related traits impacting evolutionary fitness. Autozygosity (FROH) is typically measured from runs of homozygosity (ROHs) that arise when identical-by-descent (IBD) haplotypes are inherited from each parent. Population isolates with a small set of common founders have...

Topics

Humans
Amish
Multifactorial Inheritance
Polymorphism, Single Nucleotide
Genome
Homozygote
Inbreeding

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Identifiers

PMID: 36941539
DOI: 10.1186/s12864-023-09208-5
PMCID: PMC10029202

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