Article
Detection and quantification of inbreeding depression for complex traits from SNP data.
Proceedings of the National Academy of Sciences of the United States of America - 8 Aug 2017
Yengo Loic, Zhu Zhihong, Wray Naomi R, Weir Bruce S, Yang Jian, Robinson Matthew R, Visscher Peter M
Abstract excerpt
Quantifying the effects of inbreeding is critical to characterizing the genetic architecture of complex traits. This study highlights through theory and simulations the strengths and shortcomings of three SNP-based inbreeding measures commonly used to estimate inbreeding depression (ID). We demonstrate that heterogeneity in linkage disequilibrium (LD) between causal variants and SNPs biases ID estimates, and we...
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