Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Relationships between estimated autozygosity and complex traits in the UK Biobank.

PLoS genetics - 1 Jul 2018

Johnson Emma C, Evans Luke M, Keller Matthew C

Abstract excerpt

Inbreeding increases the risk of certain Mendelian disorders in humans but may also reduce fitness through its effects on complex traits and diseases. Such inbreeding depression is thought to occur due to increased homozygosity at causal variants that are recessive with respect to fitness. Until recently it has been difficult to amass large enough sample sizes to investigate the effects of inbreeding depression...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over
Share to Biological Specimen Banks
Share to Consanguinity

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genome, Human

Share to Genotyping Techniques

Share to Homozygote

Share to Multifactorial Inheritance

Share to United Kingdom

Source

Open in PubMed Open full text

Identifiers

PMID: 30052639
DOI: 10.1371/journal.pgen.1007556
PMCID: PMC6082573

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Relationships between estimated autozygosity and complex traits in the UK Biobank.PMID 30052639Read ↗

Relationships between estimated autozygosity and complex traits in the UK BiobankSemantic proximity Read ↗

Associations of autozygosity with a broad range of human phenotypes.Semantic proximity Read ↗

Weighted likelihood inference of genomic autozygosity patterns in dense genotype dataSemantic proximity Read ↗

The association of genotype-based inbreeding coefficient with a range of physical and psychological human traits.Semantic proximity Read ↗

Weighted likelihood inference of genomic autozygosity patterns in dense genotype data.Semantic proximity Read ↗

Genetics of consanguinity and inbreeding in health and diseaseSemantic proximity Read ↗

Genome-wide autozygosity is associated with lower general cognitive ability.Semantic proximity Read ↗

Genomic partitioning of inbreeding depression in humans.Semantic proximity Read ↗

Influence of autozygosity on common disease risk across the phenotypic spectrumSemantic proximity Read ↗

Influence of autozygosity on common disease risk across the phenotypic spectrum.Semantic proximity Read ↗

Detection and quantification of inbreeding depression for complex traits from SNP data.Semantic proximity Read ↗

The coefficients of inbreeding revealed by ROH study among inbred individuals belonging to each type of the first cousin marriage: A preliminary report from North India.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.