Article

Relationships between estimated autozygosity and complex traits in the UK Biobank

2018-03-29

Abstract excerpt

Inbreeding increases the risk of certain Mendelian disorders in humans but may also reduce fitness through its effects on complex traits and diseases. Such inbreeding depression is thought to occur due to increased homozygosity at causal variants that are recessive with respect to fitness. Until recently it has been difficult to amass large enough sample sizes to investigate the effects of inbreeding depression on...

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Literature Corpus work: 9ac7b363-ac66-5ab8-bfca-fcdf84a5a1a5
DOI: 10.1101/291872

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