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Article

Separable functions of Tof1/Timeless in intra-S-checkpoint signalling, replisome stability and DNA topological stress.

Nucleic acids research - 2 Dec 2020

Westhorpe Rose, Keszthelyi Andrea, Minchell Nicola E, Jones David, Baxter Jonathan

Abstract excerpt

The highly conserved Tof1/Timeless proteins minimise replication stress and promote normal DNA replication. They are required to mediate the DNA replication checkpoint (DRC), the stable pausing of forks at protein fork blocks, the coupling of DNA helicase and polymerase functions during replication stress (RS) and the preferential resolution of DNA topological stress ahead of the fork. Here we demonstrate that...

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Identifiers

PMID: 33166393
DOI: 10.1093/nar/gkaa963
PMCID: PMC7708041

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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