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Swi1Timeless Prevents Repeat Instability at Fission Yeast Telomeres

18 Mar 2016

Abstract excerpt

Genomic instability associated with DNA replication stress is linked to cancer and genetic pathologies in humans. If not properly regulated, replication stress, such as fork stalling and collapse, can be induced at natural replication impediments present throughout the genome. The fork protection complex (FPC) is thought to play a critical role in stabilizing stalled replication forks at several known replication...

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Share to DNA Repair Mechanisms
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PMID: 26990647
DOI: 10.1371/journal.pgen.1005943

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