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Article

Ctf4 Is a Hub in the Eukaryotic Replisome that Links Multiple CIP-Box Proteins to the CMG Helicase.

Molecular cell - 4 Aug 2016

Villa Fabrizio, Simon Aline C, Ortiz Bazan Maria Angeles, Kilkenny Mairi L, Wirthensohn David, Wightman Mel, Matak-Vinkovíc Dijana, Pellegrini Luca, Labib Karim

Abstract excerpt

Replisome assembly at eukaryotic replication forks connects the DNA helicase to DNA polymerases and many other factors. The helicase binds the leading-strand polymerase directly, but is connected to the Pol α lagging-strand polymerase by the trimeric adaptor Ctf4. Here, we identify new Ctf4 partners in addition to Pol α and helicase, all of which contain a "Ctf4-interacting-peptide" or CIP-box. Crystallographic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27397685
DOI: 10.1016/j.molcel.2016.06.009
PMCID: PMC4980431

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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