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Article

Fork rotation and DNA precatenation are restricted during DNA replication to prevent chromosomal instability.

Proceedings of the National Academy of Sciences of the United States of America - 18 Aug 2015

Schalbetter Stephanie A, Mansoubi Sahar, Chambers Anna L, Downs Jessica A, Baxter Jonathan

Abstract excerpt

Faithful genome duplication and inheritance require the complete resolution of all intertwines within the parental DNA duplex. This is achieved by topoisomerase action ahead of the replication fork or by fork rotation and subsequent resolution of the DNA precatenation formed. Although fork rotation predominates at replication termination, in vitro studies have suggested that it also occurs frequently during...

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Identifiers

PMID: 26240319
DOI: 10.1073/pnas.1505356112
PMCID: PMC4547287

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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