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Article

Timeless preserves telomere length by promoting efficient DNA replication through human telomeres

11 Jun 2012

Abstract excerpt

A variety of telomere protection programs are utilized to preserve telomere structure. However, the complex nature of telomere maintenance remains elusive. The Timeless protein associates with the replication fork and is thought to support efficient progression of the replication fork through natural impediments, including replication fork block sites. However, the mechanism by which Timeless regulates such...

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Identifiers

PMID: 22672906
DOI: 10.4161/cc.20810

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Related research

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Timeless preserves telomere length by promoting efficient DNA replication through human telomeresPMID 22672906Read ↗

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TRFH domain is critical for TRF1-mediated telomere stabilization.Semantic proximity Read ↗

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Requirement of DDX39 DEAD box RNA helicase for genome integrity and telomere protectionSemantic proximity Read ↗

Human TEN1 Maintains Telomere Integrity and Functions in Genome-wide Replication RestartSemantic proximity Read ↗

Characterization of t-loop formation by TRF2Semantic proximity Read ↗

Involvement of human ORC and TRF2 in pre‐replication complex assembly at telomeresSemantic proximity Read ↗

The Replisome Pausing Factor Timeless Is Required for Episomal Maintenance of Latent Epstein-Barr VirusSemantic proximity Read ↗

Loss of DNA replication fork protection by TIMELESS degradation supports oncogene-induced senescenceSemantic proximity Read ↗

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