Article
Multiomics profiling of primary lung cancers and distant metastases reveals immunosuppression as a common characteristic of tumor cells with metastatic plasticity.
Genome biology - 4 Nov 2020
Lee Won-Chul, Reuben Alexandre, Hu Xin, McGranahan Nicholas, Chen Runzhe, Jalali Ali, Negrao Marcelo V, Hubert Shawna M, Tang Chad, Wu Chia-Chin, Lucas Anthony San, Roh Whijae, Suda Kenichi, Kim Jihye, Tan Aik-Choon, Peng David H, Lu Wei, Tang Ximing, Chow Chi-Wan, Fujimoto Junya, Behrens Carmen, Kalhor Neda, Fukumura Kazutaka, Coyle Marcus, Thornton Rebecca, Gumbs Curtis, Li Jun, Wu Chang-Jiun, Little Latasha, Roarty Emily, Song Xingzhi, Lee J Jack, Sulman Erik P, Rao Ganesh, Swisher Stephen, Diao Lixia, Wang Jing, Heymach John V, Huse Jason T, Scheet Paul, Wistuba Ignacio I, Gibbons Don L, Futreal P Andrew, Zhang Jianhua, Gomez Daniel, Zhang Jianjun
Abstract excerpt
BACKGROUND: Metastasis is the primary cause of cancer mortality accounting for 90% of cancer deaths. Our understanding of the molecular mechanisms driving metastasis is rudimentary. RESULTS: We perform whole exome sequencing (WES), RNA sequencing, methylation microarray, and immunohistochemistry (IHC) on 8 pairs of non-small cell lung cancer (NSCLC) primary tumors and matched distant metastases. Furthermore, we...
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